Note: More up to date information regarding RA pathogenesis may be found in lectures given by the author on this website.Immune Mediated Inflammatory DiseaseIn the last decade we have significantly increased our knowledge of the underlying pathobiology of rheumatoid arthritis. The introduction of targeted biological therapy has provided experiential rather than experimental evidence that multiple different immunological and inflammatory pathways are operative. Each year there are descriptions of new cytokines, mediators, and pathways that show additional promise in unraveling the complex pathobiological pathways.Rheumatoid arthritis is best characterized as an immune mediated inflammatory disease (IMID). Within a framework that recognizes both immunological activation and inflammatory pathways, we can begin to evaluate the multiple components of disease initiation and propagation.
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